This review article investigated the factors that contributed to the COVID-19 vaccine hesitancy in South Asian Americans and other communities of color in the US. Only a few studies were done on South Asian Americans. The factors contributing to COVID-19 vaccine hesitancy in South Asian Americans were: concerns about the safety and lack of access to healthcare (language  barrier). Many other factors found in other communities of color in the US were:  lower education, lower income, younger people, women, rural residents, conservative/Republican political bias, social media’s influence, lack of trust in government, and previous adherence (pre-pandemic) to general immunization. We recommend the following strategies to increase vaccination rates among South Asian Americans: Develop health education/messaging programs for South Asian Americans that are culturally and linguistically appropriate. Include social media influencers and the medical community early in messaging strategies. Invest more on research on South Asian Americans to find which other factors also affect these communities. COVID-19 vaccine hesitancy in South Asian Americans exists and should be addressed just like in every other community of color in the US. Information is very much needed to raise the awareness about the need for vaccines, increase vaccination rates, find strategies for overcoming vaccine hesitancy, and significantly reduce morbidity and mortality from COVID-19.