Liver cancer presents a significant global health burden, with most cases diagnosed at advanced stages, leadingtopooroutcomes. Identifying modifiable risk factors is essential for primary prevention. Established risk factors includechronichepatitis B and C infections, heavy alcohol consumption, obesity, diabetes, and aflatoxin exposure. However, manycasesremain unexplained, suggesting dietary and other environmental influences. Vitamin D, traditionally recognizedfor itsroleinbone health, has been increasingly studied for its regulatory effects on inflammation and immune function. Over thepastdecade, research has explored vitamin D’s potential in cancer prevention, particularly in colon, breast, pancreatic, prostate,and liver cancers. This systematic review examines the role of vitamin D in liver cancer, including its metabolism, molecularpathways, treatment possibilities, and limitations.